Premenstrual Exacerbation (PME) refers to the premenstrual exacerbation/worsening of the symptoms of another disorder, such as major depressive disorder or generalized anxiety disorder.
Premenstrual Dysphoric Disorder (PMDD) is a cyclical mood disorder with symptoms that arise during the premenstrual or luteal phase of the menstrual cycle which subside within a few days of menstruation.
The vast majority of women/AFAB with PMDD have normal hormone levels. PMDD appears to be a negative response to the normal fluctuations in female reproductive hormone levels.
